Ageing Seminars 2025 - Dr. Marco Candeias
On September 8th , at 11.00am, Lisbon time, we welcome Doctor Marco Candeias, who will be presenting “Ageing control by p53: Enters Δ246p53 isoform, a new player in DNA damage response”.The seminar will be held at Auditório da Admistração, ground floor, Faculty of Medicine (Polo I), University of Coimbra and Online. For online attendance, registration is mandatory through this link. Registered participants will receive the a link one day before the seminar.
Summary: Many diseases from dementia to heart failure, degenerative diseases, cancer and even the natural ageing process, all result from a loss of adequate cell function in specialized tissues. p53 has been associated with all these conditions, but the mechanisms are unclear. In our lab we have observed that different cell types show unique and characteristic p53 product profiles and that manipulating them alters cell behaviour and fate. By investigating the presence, regulation and role of p53 (in all its forms) in different cells, tissues and organs, we want to gain insight on how p53 manages each different cell type. We hope to understand the exact role of the different p53 products and their regulation in specific cells and tissues in order to help protect these cells (and subsequently the organism) from disease, degeneration, transformation and ageing.
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